Healthspan and Longevity Research and Science
Discover and fund research focused on both improving our understanding of the aging process and uncovering protocols and medicines to help us live longer, better.
Projects
The Dog Aging Project
“The Dog Aging Project is doing important research to answer valuable questions around aging and longevity. I'm happy to be a donor and supporter of this project.”
Peter Attia, Physician
Health and Longevity Research in popular media
#10 - Matt Kaeberlein, Ph.D.: rapamycin and dogs — man’s best friends? — living longer, healthier lives and turning back the clock on aging, and age-related diseases
GUEST SERIES | Dr. Andy Galpin: Optimal Protocols to Build Strength & Grow Muscles
#85 - Iñigo San Millán, Ph.D.: Mitochondria, exercise, and metabolic health
GUEST SERIES | Dr. Andy Galpin: How to Build Physical Endurance & Lose Fat
Dr. Peter Attia on Mastering Longevity – Insights on Cancer Prevention, Heart Disease, and Aging
How to Build Strength, Muscle Size & Endurance
Recent Publications
An open science study of ageing in companion dogs | Creevy, K.E., Akey, J.M., Kaeberlein, M. et al. | 2022 | Nature
The Dog Aging Project is a long-term longitudinal study of ageing in tens of thousands of companion dogs. The domestic dog is among the most variable mammal species in terms of morphology, behaviour, risk of age-related disease and life expectancy... Read more
The Dog Aging Project: Translational Geroscience in Companion Animals | Kaeberlein M, Creevy KE, Promislow DE.| 2016 | Mamm Genome
Studies of the basic biology of aging have identified several genetic and pharmacological interventions that appear to modulate the rate of aging in laboratory model organisms, but a barrier to further... Read more
A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs | Urfer SR, Kaeberlein TL, Mailheau S, et al. | 2017 | Geroscience
Age is the single greatest risk factor for most causes of morbidity and mortality in humans and their companion animals. As opposed to other model organisms used to study aging, dogs share the human environment... Read more
DNA methylation and chromatin accessibility predict age in the domestic dog | Daniel E. L. Promislow et al. | 2024 | Aging Cell
Across mammals, the epigenome is highly predictive of chronological age. These “epigenetic clocks,” most of which have been built using DNA methylation (DNAm) profiles, have gained traction as biomarkers of aging and organismal health. While the ability of DNAm to predict chronological... Read more
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