Unlocking potential treatments for biliary tract cancers by studying the DNA of advanced patients

This study aims to use genetic sequencing to explore this rare, deadly and underfunded disease so the data can be mined and used to develop more effective and personalized treatments.

Princess Margaret Cancer Centre
Princess Margaret Cancer Centre
Toronto, Canada
Dr. Steve GallingerDr. Grainne O’Kane

Dr. Steve Gallinger

Dr. Grainne O’Kane

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Project Summary

Biliary tract cancers (BTCs) refer to a group of cancers that include gallbladder cancer (GBC) and bile duct cancer. BTCs are rare but on the rise, and those who are diagnosed face limited options and a very high mortality rate. There hasn’t been a lot of progress in the treatment of BTCs because the biology of these tumors is still poorly understood.

The purpose of this study is to better understand the biology of biliary tract cancers, so we can know why they develop and what treatments are best.

We plan to recruit 60-90 patients over 3 years. We will collect blood and tumor samples from these patients to study BTCs on a molecular level and then use this information to build a database that we can share with researchers around the world.