Which rheumatoid arthritis drug works for me?

Rheumatoid arthritis patients have to go through a series of drugs before finding one that works for them. While trying out firstline drugs such as methotrexate, many patients experience a series of debilitating side-effects, such as nausea, fatigue, and infections, causing them to discontinue their usage. Currently, there are limited tests available to tell a patient whether a drug will work for them, which could potentially save them time, money, and prevent a painful experience. Tools such as single-cell RNA sequencing provide high-resolution snapshots into the behavior of many different immune cells in a person’s blood. By combining single-cell immune profiling and at-home capillary blood self-collection, we are looking to understand why first line of defense drugs work for some people and not others. For a behind-the-scenes view of how we made this study happen, check out our blog on Medium!